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LRRK2 activation controls the repair of damaged endomembranes …
Web27 mrt. 2024 · In follow-up functional assays, we demonstrated that LRRK2 and NOD2 proteins physically interact in macrophages and that this interaction was strongly impacted by the NOD2 variant. Furthermore, we showed a joint effect of LRRK2 and NOD2 variants that results in a reduced antimycobacterial response in these cells. Webmediated through LRRK2 phosphorylated Rab8/10 interaction with RILPL1/2 (Fig). Inflammation plays an important role in the development of Parkinson’s. LRRK2 is highly expressed in macrophages, monocytes and neutrophils suggesting it functions in the defence against intracellular pathogens. pottery and mental health
LRRK2 is a negative regulator of Mycobacterium …
Web1 dec. 2024 · LRRK2 protects RAW macrophages against erastin effects. B. LRRK2 depletion reduces the glycolytic function and L-leucine metabolism, while inhibition of … Web10 apr. 2024 · On the other hand, there is data showing that cells bearing leucine-rich repeat kinase 2 (LRRK2), a signaling molecule with genetic variants associated with both PD and with inflammatory bowel... Web7 nov. 2024 · Researchers observed that mutated macrophages were more prone to die after infection when compared with controls, but also that the infection triggered a switch … pottery and fountains orange county ca