Jerantinine
Web28 giu 2024 · The development of an asymmetric and highly convergent three-component synthesis of the functionalized ABC ring system of the Aspidosperma alkaloid … WebOrigine e diffusione. Si tratta di un diminutivo di Jeanne, la forma francese del nome Giovanna.. La variante Janine è moderna, in uso dal XX secolo.Secondo alcune fonti sarebbe direttamente derivata da Jeannine, mentre altre la interpretano come una elaborazione di Jane (la forma inglese di Giovanna), combinata con la terminazione in …
Jerantinine
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Web1 mar 2024 · Abstract. A concise semi-synthesis of the Aspidosperma alkaloids, (−)-jerantinine A and (−)-melodinine P, and derivatives thereof, is reported. The novel … Web31 ott 2015 · Jerantinine B is a natural indole alkaloid with strong anticancer activity, but at high doses, it may be cytotoxic to normal cells and cause adverse effects [99].
Web14 ott 2013 · Nature's beauty : The first total synthesis of the alkaloid natural product jerantinine E is based on a selective cyclization of an aminocyclopropane. Preliminary investigations show that it inhibits the polymerization of tubulin, displaying significant cytotoxicity and antimigratory activity against both breast and lung cancer cell lines. Web14 ott 2013 · Nature's beauty: The first total synthesis of the alkaloid natural product jerantinine E is based on a selective cyclization of an aminocyclopropane. Preliminary …
WebDownload scientific diagram Crystal structure of the tubulin-jerantinine B acetate (9) complex. (A) Overall view of the T 2 RTTL-jerantinine B acetate complex structure. The α-and β-tubulin ... Web28 gen 2016 · Jerantinine B (JB) is one of seven novel Aspidosperma indole alkaloids isolated from the leaf extract of Tabernaemontana corymbosa. Preliminary antiproliferative assays revealed that JB and JB acetate significantly inhibited growth and colony formation, accompanied by time- and dose-dependent apoptosis induction in human cancer cell lines.
WebS1 Supporting Information Development of a βC–H Bromination Approach Towards the Synthesis of Jerantinine E Tatjana Huber,1,† Teresa A. Preuhs,1,† Christa K. G. Gerlinger,2 and Thomas Magauer*,1,3 1Department of Chemistry, Ludwig-Maximilians-University, 81377 Munich, Germany. 2Faculty of Chemistry, University of Konstanz, …
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