2024 Carboxyatractylate

Carboxyatractylate

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August undefined, 2024

WebCarboxyatractylate was able to inhibit UCP3, probably through an indirect mechanism. Our results are consistent with the conclusion that, in skeletal muscle, HNE-induced increase … WebBased on these studies, mechanism of the ADP/ATP antiporter involvement in the uncoupling induced by fatty acids was proposed. New data (suppression by carboxyatractylate of the SDS-induced uncoupling, pH-dependence of the ADP/ATP and the glutamate/aspartate antiporter contributions to the uncoupling, etc.) led to …

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WebCarboxyatractyloside ( CATR) is a highly toxic diterpene glycoside that inhibits the ADP/ATP translocase. It is about 10 times more potent than its analog atractyloside. [1] … WebAug 8, 1978 · The intact carboxyatractylate . protein complex is protected against proteolytic degradation. The release of carboxyatractylate ensues a conformational … major scale backing track

Irina GOSTIMSKAYA Research Associate PhD in Biochemistry

WebOct 1, 2002 · The channel corresponds to a preferential matrix-outside orientation of rAAC in the patch membrane as shown with carboxyatractylate and a polar gating asymmetry. The channel is inhibited by ADP and bongkrekate, not by carboxyatractylate. WebApr 25, 2008 · Inhibition of this endogenous activation by GDP [classically considered specific for UCPs (uncoupling proteins)], carboxyatractylate and bongkrekate (considered specific for the adenine nucleotide translocase) was examined in skeletal muscle mitochondria from wild-type and Ucp3 -knockout mice. WebSep 17, 1984 · An organ-specific inhibition of the nucleotide transport in heart mitochondria by the heart carboxyatractylate-protein antiserum leads to the conclusion that the organ specificity is at least partially conditioned by the binding site for the substrate and/or the closely linked gate of the carrier protein. majors burger co

Role of the ADP/ATP and aspartate/glutamate antiporters …

Use of carboxyatractylate and tight-binding inhibitor theory to ...

WebThe effects of carboxyatractylate (CAtr) on delta psi in sunflower hypocotyl and pea stem mitochondria were compared. In sunflower mitochondria, (1) CAtr at higher concentration … WebCarboxyatractylate C31H46O18S2 CID 108174 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and … major scale boxes bassWebOct 15, 1990 · In the oligomycin-treated mitochondria, carboxyatractylate, an inhibitor of the ATP/ADP-antiporter, is shown to decrease the respiration rate, to increase the membrane potential and to lower the rate of the membrane-potential discharge after the addition of cyanide to liver mitochondria from hibernating and arousing animals. major scale and relative minor scale chart

"WebThe efficien of thce inhibitorsy was checked using different concentrations of carboxyatractylate (CAT) between 10 and 500 µM. If 10 µΜ CAT is large enough to block completely the exc it dhoanes... " - Carboxyatractylate

Carboxyatractylate

Incorporation of N-ethylmaleimide into the membrane-bound …

WebThe functioning of mitochondria and their biogenesis are largely based on the proper function of the mitochondrial outer membrane channels, which selectively recognise and import proteins but also transport a wide range of other molecules, including metabolites, inorganic ions and nucleic acids. To date, nine channels have been identified in the … WebAug 8, 1978 · The intact carboxyatractylate · protein complex is protected against proteolytic degradation. The release of carboxyatractylate ensues a conformational …

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WebCarboxyatractylate inhibits the potentiating effect of lipophylic cation TPP+ on uncoupling activity of fatty acid Authors V I Dedukhova 1 , E N Mokhova , A A Starkov , Leikin YuN Affiliation 1 A.N. Belozersky Institute of Physical-Chemical Biology, Moscow State University, Russia. PMID: 8220260 Abstract WebSep 18, 1998 · Carboxyatractylate, an ATP/ADP antiporter inhibitor, abolishes the laurate inhibition, the CCCP inhibition being unaffected. Atractylate partially releases the …

WebCarboxyatractylate was able to inhibit UCP3, probably through an indirect mechanism. Our results are consistent with the conclusion that, in skeletal muscle, HNE-induced increase …

WebEthanol taken at concentration of 0.25 M had no effect on the uncoupling activity of palmitic acid in the presence of 2 mM MgCl2 and decreased the recoupling effects of … WebOct 1, 2010 · The possibility that carboxyatractylate indirectly inhibits UCP3 in the heart cannot be excluded. An alternative explanation is that HNE induces a conformational …

WebJun 22, 1992 · Thermoregulatory, carboxyatractylate-sensitive uncoupling in heart and skeletal muscle mitochondria of the ground squirrel correlates with the level of free fatty …

WebIt belongs to a family of reversible decarboxylases that interconvert propenoic or aromatic acids with the corresponding alkenes or aromatic compounds using a prenylated flavin mononucleotide... major scale chord chart guitarWebJul 1, 2010 · To clarify this we studied the sensitivity of HNE-activated proton conductance to GDP (UCPs inhibitor) and carboxyatractylate (ANT inhibitor) in skeletal-muscle and heart mitochondria from mice... major scale hand signsWebApr 1, 1993 · Carboxyatractylate (CAT) is a highly selective inhibitor of the AdNT, with K i < 10 nM, a value sufficiently low relative to the concentration of protein in transport assays … major scale interval chartWebCarboxyatractylate (CAT) is a highly selective inhibitor of the AdNT, with Ki < 10 nM, a value sufficiently low relative to the concentration of protein in transport assays to suggest the use of tight-binding inhibitor theory to quantify functional translocators. Ackermann-Potter plots of velocity vs proteoliposome concentration at several ... major scale chord chartWebDec 10, 2010 · The carboxyatractylate-sensitive hydroxynonenal stimulation correlated with ANT content in mitochondria from Drosophila melanogaster expressing different amounts of ANT. Our findings indicate that ... major scale fretboard chartWebDescription: Carboxyatractyloside is a highly toxic diterpene glycoside that inhibits the ADP/ATP translocase. It's about 10 times more potent than atractyloside. While atractyloside is effective in the inhibition of oxidative phosphorylation, carboxyatractyloside is considered to be more effective. Chemical Structure Carboxyatractyloside major scale first position guitarWebThe portion of uncoupling acc tivity of laurate, sensitive to carboxyatractylate or to glutamate was determined from the ratio ∆J u / [U], where ∆J u -the value of inhibition of … major scale fingerings piano